. Author manuscript; available in PMC: 2023 Feb 15.

Published in final edited form as: Curr Treat Options Oncol. 2022 Feb 15;23(1):29–42. doi: 10.1007/s11864-021-00926-0

Table 1:

Additional medication treatment options for CIPN

Mechanism	Drugs	References

Sodium channel blockers	Lacosamide, mexiletine, tocainide, parenternal lidocaine	[3, 61]

NMDA receptor antagonists	Ketamine (topical)	[62, 63]

GABA_A receptor agnoists	Clonazepam (and other benzodiazepines)	[64]

GABA_B receptor agonists	Baclofen	[62, 65]

Alpha-2 adrenergic agonists	Tizanidine	[66]

Anticonvulsants	Oxcarbazepine, lacosamide	[67, 68]

Cannabinoids	Nabiximols, dronabinol	[69] Animal models: [70–72]

Topical agents	Capsaicin	[73, 74]
	Lidocaine	[75]
	Menthol	[76, 77]