Table 3.

The Top miRNA-Regulated Genes Targeting miRNAs That Were Identified as Significantly Dysregulated in the Exacerbating and Stable State COPD Cohorts, as Well as GOLD Classified Cohorts

Patient Groups	Gene	miRNAs Targeting this Gene	Total # of Target Sites Identified in Target Gene	Range of Strength Scores (Min to Max)
Exacerbating vs stable state	Genes regulated by significantly under-expressed miRNA
	HCN3	hsa-miR-34a-5p	4	−0.359 to −0.182
	NAV1	hsa-miR-34a-5p	4	−0.25–0.041
	NDST1	hsa-miR-34a-5p	3	−0.035–0.038
	SCN2B	hsa-miR-34a-5p	3	−0.21 to −0.059
	ANKRD52	hsa-miR-34a-5p	2	−0.12 to −0.029
	Genes regulated by significantly over-expressed miRNAs
	AFF1	hsa-miR-92b-3p	5	−0.3665 to −0.286
		hsa-miR-374a-5p
	FBXW7	hsa-miR-223-3p	5	−0.547 to −0.197
		hsa-miR-92b-3p
	MEF2D	hsa-miR-374a-5p	4	−0.391 to −0.112
		hsa-miR-92b-3p
		hsa-miR-223-3p
	AFF4	hsa-miR-92b-3p	4	−0.275 to −0.032
		hsa-miR-374a-5p
	HLF	hsa-miR-223-3p	4	−0.183 to −0.0652
		hsa-miR-374a-5p
GOLD Severe/ very severe vs GOLD Moderate	Genes regulated by significantly over-expressed miRNA
	AFF1	hsa-miR-374b-5p	4	−0.337 to −0.318
	ACVR2B	hsa-miR-374b-5p	3	−0.603 to −0.232
	PCDH10	hsa-miR-374b-5p	3	−0.304 to −0.146