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. 2022 Oct 21;3(1):sgac067. doi: 10.1093/schizbullopen/sgac067

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© The Author(s) 2022. Published by Oxford University Press on behalf of the University of Maryland's school of medicine, Maryland Psychiatric Research Center.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 2. — Dopamine synthesis capacity in the striatal subregions of MAM-treated rats was significantly elevated. [³H]DOPA ex vivo autoradiography studies indicated a significant increase in dopamine synthesis capacity in the caudate putamen (CPU) and nucleus accumbens (NAc) of MAM-treated rats when compared with saline-treated controls (A), which was not influenced by intrahippocampal injections of NMDA in saline-treated controls to acutely activate the vHipp (B), and TTX in MAM-treated rats to acutely inhibit vHipp activity (C). Representative sections in saline- and MAM-treated rats depicting increased granular accumulation in the striatum of MAM-treated rats (D). White dotted lines indicated subregions that were analyzed. # denotes a significant main effect of MAM. P = .013. Note: MAM, methylazoxymethanol acetate; NMDA, N-methyl-d-aspartate.