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Dopamine neuron population activity in the ventral tegmental area (VTA) correlates with presynaptic dopamine release in the striatum. Under control conditions, approximately half of the dopamine neurons in the VTA are spontaneously active. In the case of psychosis, a significant increase in VTA population activity, or number of spontaneously active dopamine neurons in the VTA, yields an increase in presynaptic dopamine synthesis capacity/release in the striatum.
