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. 2022 Nov 4;15:3493–3507. doi: 10.2147/JPR.S378876

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© 2022 Anand et al.

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2-AG mediated calcium influx. Graph showing responses to 1 µMol capsaicin (1st bar), compared with dose-related responses to application of 2-AG (bars 2, 3, 4) *P<0.05 (A). Graph showing latency of capsaicin responses in control neurons (1st bar, N= 16), and its significant increase due to 2-AG (2nd bar, N=10). This increased latency was sensitive to the CB₂ receptor antagonist (3rd bar, N= 3), but not to CB₁ receptor antagonist (4th bar, N=5). The presence of the MAGL inhibitor JZL184 reversed the increased latency (5th bar, N= 3), but the phosphatase inhibitor cyclosporine had no effect (6th bar, N= 3). ***P<0.001 (B).