Table 3.
2-PG Concentration | µMol | 0 | 0.0001 | 0.001 | 0.01 | 0.1 | 1 | 5 | 10 | 30 | 60 | 100 |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Capsaicin Response Amplitude | 340/380 Ratio mean ± sem | 0.16 ± 0.01 | 0.13 ± 0.01 | 0.08 ± 0.02 | 0.12 ± 0.03 | 0.13 ± 0.02 | 0.11 ± 0.03 | 0.17 ± 0.01 | 0.16 ± 0.05 | 0.18 ± 0.01 | 0.16 ± 0.04 | 0.19 ± 0.03 |
Capsaicin Response Latency | Seconds mean ± sem | 1.77 ± 0.3 | 284.7 ± 21 | 331.6 ± 25 | 302.6 ± 27 | 272.5 ± 17 | 328.2 ± 16 | 299.2 ± 33 | 404.9 ± 57 | 254 ± 36 | 351 ± 33 | 347 ± 47 |
N | Rats | 16 | 3 | 3 | 4 | 5 | 6 | 7 | 6 | 6 | 3 | 6 |
Total no. | Neurons | 176 | 19 | 16 | 26 | 49 | 35 | 88 | 66 | 70 | 42 | 68 |
Notes: Data showing the increased capsaicin response latency in the presence of 2-PG from 0.0001 to 100 µMol. Effects on capsaicin response amplitude were similar to control values.