Skip to main content
. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Alzheimers Dement. 2021 May 13;18(1):29–42. doi: 10.1002/alz.12365
Immediate actions for implementation Next actions for implementation Medium term development of harmonized assessment
If possible, use cUDS as from Table 1
If not possible, adopt local analogues (differences in administration order are admitted, when the cUDS tests are already used in local batteries guaranteeing appropriate administration relative to delay, interference, etc.)
Define a standard format for data entry and for the clinical report
Coordinate next steps consistently across countries to get aligned as much as possible (e.g., exact version of tests)
Extend representativeness of the consortium
Perform survey to explore feasibility, hurdles, facilitators and needs for implementing cUDS in academic and non-academic memory clinics
Potentiate reciprocal connection of research and clinical centers
Offer services to clinicians, to:
• connect and receive feedback support compliance to harmonization
• Define copyright-free cUDS tests in the same way as done for UDS-3 (1)
• Provide local norms with the harmonized methodology proposed here (labs of neuropsychology)
• Bridge with pertinent stakeholders (e.g., health refunders, regulators) for consistent implementation
• Identify tests most needed to complete appropriately cUDS (uncovered domains; actual administration time & tasks for interference/delay; etc.)
Adapt tests across European cultures and languages Develop alternate test versions for repeated testing Validate cUDS:
• For most widespread languages first
• for the 27 EU languages (include language variant sub-samples in main languages)
• based on the defined harmonized methods both paper-pencil and tablet version if available
• Define backwards compatibility to shift from currently used batteries to the standard
• Disseminate the information about cUDS implementation capillary through clinical and professional networks and Scientific Societies Adapt tests for digitally-assisted assessment (tablet)
• Converge informatics experts and entrepreneurs to overcome issues on digitally-assisted assessment Possibly include more, or more sensitive, tests, thanks to digital advancements
• Keep developing hypothesis-driven and culture-free tests, and validate them based on the consensually defined methodology
• Consider the use of robust controls to compare, and possibly improve, normative values and test sensitivity in the future
• Select newly developed tests based on diagnostic performance
• Fine-tune cUDS and implementation based on consensus with all stakeholders

1. Weintraub S, Besser L, Dodge HH, Teylan M, Ferris S, Goldstein FC, et al. Version 3 of the Alzheimer Disease Centers’ Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Assoc Disord. marzo 2018;32(1):10–7.