Table 1. Cohort demographics by adherence pattern at 12 weeks.
| High (n = 483) | Moderate (n = 93) | Low (n = 20) | P-value | Overall (n = 596) | |
|---|---|---|---|---|---|
| Age | |||||
| Median [Min, Max] | 40.0 [14.0, 76.0] | 41.0 [19.0, 75.0] | 42.0 [22.0, 64.0] | 0.39 | 41.0 [14.0, 76.0] |
| Sex | |||||
| Male | 339 (70.2%) | 61 (65.6%) | 14 (70.0%) | 0.68 | 414 (69.5%) |
| Female | 144 (29.8%) | 32 (34.4%) | 6 (30.0%) | 182 (30.5%) | |
| Resistance category | |||||
| MDR | 249 (51.6%) | 45 (48.4%) | 8 (40.0%) | 0.64 | 302 (50.7%) |
| Pre-XDR | 225 (46.6%) | 47 (50.5%) | 11 (55.0%) | 283 (47.5%) | |
| XDR | 9 (1.9%) | 1 (1.1%) | 1 (5.0%) | 11 (1.8%) | |
| Year of initiation | |||||
| 2012 | 9 (1.9%) | 1 (1.1%) | 0 (0%) | 0.53 | 10 (1.7%) |
| 2013 | 47 (9.7%) | 9 (9.7%) | 4 (20.0%) | 60 (10.1%) | |
| 2014 | 128 (26.5%) | 17 (18.3%) | 3 (15.0%) | 148 (24.8%) | |
| 2015 | 206 (42.7%) | 46 (49.5%) | 8 (40.0%) | 260 (43.6%) | |
| 2016/17 | 93 (19.3%) | 20 (21.5%) | 5 (25.0%) | 118 (19.8%) | |
| Region | |||||
| Ilocos Region | 2 (0.4%) | 1 (1.1%) | 0 (0%) | 0.88 | 3 (0.5%) |
| Cagayan Valley | 43 (8.9%) | 4 (4.3%) | 2 (10.0%) | 49 (8.2%) | |
| Central Luzon | 5 (1.0%) | 1 (1.1%) | 0 (0%) | 6 (1.0%) | |
| Calabarzon | 93 (19.3%) | 17 (18.3%) | 4 (20.0%) | 114 (19.1%) | |
| Mimaropa | 13 (2.7%) | 3 (3.2%) | 1 (5.0%) | 17 (2.9%) | |
| Bicol Region | 28 (5.8%) | 11 (11.8%) | 1 (5.0%) | 40 (6.7%) | |
| Northern Mindanao | 6 (1.2%) | 0 (0%) | 0 (0%) | 6 (1.0%) | |
| Davao Region | 4 (0.8%) | 0 (0%) | 0 (0%) | 4 (0.7%) | |
| Soccsksargen | 36 (7.5%) | 8 (8.6%) | 0 (0%) | 44 (7.4%) | |
| Caraga | 9 (1.9%) | 3 (3.2%) | 0 (0%) | 12 (2.0%) | |
| Zamboanga Peninsula | 192 (39.8%) | 34 (36.6%) | 11 (55.0%) | 237 (39.8%) | |
| Autonomous Region in Muslim Mindanao | 32 (6.6%) | 5 (5.4%) | 1 (5.0%) | 38 (6.4%) | |
| Cordillera Administrative Region | 12 (2.5%) | 5 (5.4%) | 0 (0%) | 17 (2.9%) | |
| National Capital Region | 8 (1.7%) | 1 (1.1%) | 0 (0%) | 9 (1.5%) | |
| CXR cavitation | |||||
| No | 162 (33.5%) | 41 (44.1%) | 12 (60.0%) | 0.04 | 215 (36.1%) |
| Yes | 187 (38.7%) | 27 (29.0%) | 6 (30.0%) | 220 (36.9%) | |
| Missing | 134 (27.7%) | 25 (26.9%) | 2 (10.0%) | 161 (27.0%) | |
| Sputum Grade | |||||
| Negative (0) | 74 (15.3%) | 18 (19.4%) | 3 (15.0%) | 0.77 | 95 (15.9%) |
| n+ | 61 (12.6%) | 9 (9.7%) | 0 (0%) | 70 (11.7%) | |
| 1+ | 125 (25.9%) | 23 (24.7%) | 5 (25.0%) | 153 (25.7%) | |
| 2+ | 100 (20.7%) | 21 (22.6%) | 5 (25.0%) | 126 (21.1%) | |
| 3+ | 120 (24.8%) | 20 (21.5%) | 6 (30.0%) | 146 (24.5%) | |
| Missing | 3 (0.6%) | 2 (2.2%) | 1 (5.0%) | 6 (1.0%) | |
| BMI | |||||
| Median [Min, Max] | 18.3 [9.90, 34.2] | 17.8 [11.2, 25.1] | 16.7 [11.7, 23.3] | 0.05 | 18.1 [9.90, 34.2] |
| Overall adherence proportion | |||||
| Median [Min, Max] | 83.3% [25.7%, 100%] | 51.3% [17.3%, 92.%0] | 43.4 [9.1%, 85.1%] | 0.00 | 78.7% [9.1%, 100%] |
| 12 week adherence proportion | |||||
| Median [Min, Max] | 93.1 [65.3%, 100%] | 55.6% [18.1%, 76.4%] | 39.6% [15.3%, 61.1%] | 0.00 | 91.7% [15.3%, 100%] |
| Treatment outcome | |||||
| Favorable | 327 (67.7%) | 45 (48.4%) | 2 (10.0%) | 0.00 | 374 (62.8%) |
| Unfavorable | 156 (32.3%) | 48 (51.6%) | 18 (90.0%) | 222 (37.2%) |
CXR- chest x-ray.
For the statistical tests of the distribution of variables across the adherence groups, one-way ANOVA was used for continuous variables and Χ2 test for categorical variables.