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. 2022 Oct 25;13:1009621. doi: 10.3389/fimmu.2022.1009621

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Copyright © 2022 Xu, Shi, Wang, Li, Yin, Zhang, Zhu, Jiang, Xia, Qiu, Zhang, Huang, Ma, Meng, Zhu, Dong, Wang and Yin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phylogenetic trees of patients with sMPLC. (A) 3D locations of GGOs for patients with sMPLC. All analyzed lesions were shown before and after the use of Sintilimab. The phylogenetic relationship of multiple GGOs was demonstrated for per case. (B) The comparison of genetic distance between roots and branches among all included seven patients. (C) Phylogenetic analysis on another independent dataset of sMPLC, and the comparison between rooted and branched distance was also conducted (See Methods).