Table 1.

Retrograde transduction characteristics of selected AAV serotypes in the CNS

Serotype	Region of injection	Retrograde transport target region	Reference
AAV2	hippocampus, striatum	neurons in the entorhinal cortex, medial septum, contralateral hippocampus, and substantia nigra	Kaspar et al., 2002; Passini et al., 2005
AAV2-retro	cerebellum-medial parabrachial nucleus	cerebellar purkinje cells in lobules VIII–X	Hashimoto et al., 2018
AAV2-retro	olfactory cortex	bed nucleus of the stria terminalis, anterior cortical amygdalar area, medial amygdaloid nucleus, and posteromedial cortical amygdaloid area	Zheng et al., 2020
AAV2/DJ	striatum, area X	substantia nigra, ventral tegmental area	Düring et al., 2020
AAV5	striatum, thalamus	neurons in the cortex, thalamus, and hippocampus	Pietersz et al., 2020
AAV5	hippocampus (dentate gyrus)	ipsilateral lateral entorhinal cortex	Aschauer et al., 2013
AAV8	ventral hippocampus	lateral septum and medial prefrontal cortex	Parfitt et al., 2017
AAV8	ventral tegmental area	bed nucleus of the stria terminalis	Pina and Cunningham, 2017
AAV8	striatum	substantia nigra	Masamizu et al., 2011
rAAV8	hippocampus	deep cerebellar nuclei	Bohne et al., 2019
AAV9	striatum	substantia nigra	Masamizu et al., 2011
AAV9	nucleus accumbens shell	ventral tegmental area	Li et al., 2019
AAV9	ventral tegmental area	substantia nigra	Cearley and Wolfe, 2007
AAV9	putamen	thalamic, cortical neurons, and substantia nigra	Green et al., 2016
rAAV9	primary motor cortex, visual cortex, striatum, and somatosensory cortex	thalamus, motor cortex, somatosensory cortex, contralateral primary motor cortex, lateral geniculate nucleus, substantia nigra, and motor cortex	Commisso et al., 2018
AAVrh10	ventral tegmental area	substantia nigra	Cearley and Wolfe, 2007
AAVrh10	striatum	thalamus, cortex ventral tegmental area	Piguet et al., 2012
PHP.eB	Deep cerebellar nuclei	purkinje cells	(unpublished data)