Fig. 2.

Effects of EEIV on histological appearance of colonic tissue in rats (magnification × 40): A) non colitic group with normal colonic mucosa, no lesions, and normal crypt architecture, B) control colitic group with very severe ulceration, mucosal necrosis (red arrow) with loss of crypts (white arrow), and markedly increased infiltration of neutrophils (black arrow, score 3), C) colitic group treated with EEIV at 100 mg/kg showing colon with mild lesions, partial crypt loss, and moderate inflammatory neutrophil infiltration (score 2), D) colitic group treated with EEIV at 200 mg/kg with normal colonic structure, reduction in the inflammatory infiltrate, mild edema limited mainly to the lamina propria, and minimal ulceration, E) colonic mucosa of 2.4 mg/kg dexamethasone-treated rats, F) microscopic score assigned to the different groups according to the criteria described by Fattahian et al. (2016); data are expressed as median (range) (n = 6); groups with different letters statistically differ (P < 0.05)