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. 2022 Apr 29;1(1):10–24. doi: 10.1093/lifemeta/loac002

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© The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Three patterns of linkage disequilibrium (Logarithm of the odds scores) for single-nucleotide polymorphisms (SNPs) surrounding (200 kb upstream and downstream) three example target SNPs. The pattern, in (A), is an SNP (rs4988235) adjacent to the lactase gene that shows a significant association between the target and other SNPs over a wide surrounding distance. This is indicative of a selective sweep reflecting strong positive selection in this region of the genome. The pattern, in B, for a typical obesity-related SNP (rs1499209) by contrast shows a sharp peak around the target indicative of no strong selection and similar to the pattern, in C, for a randomly selected SNP (rs1420258) (data from the International HapMap Consortium: presented in [198])