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. 2022 Oct 18;11:e77327. doi: 10.7554/eLife.77327

Figure 1. Screening of 35 ZIC lines identified three mutants with increased incidence of SA and/or AVB episodes.

(A) Representative ECG recordings for three heterozygous/homozygous GBT mutants with increased incidence of sinus arrest (SA) and/or atrioventricular block (AVB) episodes compared to WT control. (B) RP2 gene-break transposon insertional positions in the three candidate SSS mutants.

Figure 1.

Figure 1—figure supplement 1. The GBT411 mutant displayed aberrant response to autonomic stimuli.

Figure 1—figure supplement 1.

Shown are changes of HR in GBT411-/- homozygous fish at 16 months in response to different autonomic stimuli. N=9–20 animals per group, unpaired student’s t-test.