Author response table 1. Identification of the DNAJB6 variant from patients with sick sinus syndrome (n=162).

Nucleotide change (protein change)	Genotyoe frequency	ExAC MAF frequency (%)	Clinical phenotype	SIFT prediction (score)	PolyPhen Prediction (score)
c.145G>T (p.V49L)	0/8600 (EVS) 1/95768 (ExAC) 1/140242 (GnomAD) 1/162 (SSS)	0	Sick Sinus syndrome	Tolerate (o.142)	Damaging (0.972)