Table 2. ECG quantification to validate three GBT lines as SA mutants in homozygous fish.

Genotype	Age	N	SA incidence (%)	AVB incidence (%)	Heart rate (bpm)
WT	16 m	20	1 (5.0)	0 (0)	100.1±11.1
GBT103-/-	16 m	7	4 (57.1)*	1 (14.3)	89.1±9.1.
GBT410-/-	16 m	9	4 (44.4)*	0 (0)	99.9±17.7
GBT411-/-	16 m	10	4 (40.0)*	1 (10.0)	90.6±7.5*

N=7-20.

^*, p<0.05, data are expressed as mean ± SEM. For SA incidence comparison, Chi-square test. For heart rate comparison, unpaired student’s t-test.

SA, sinus arrest. AVB, atrioventricular block. bpm, beats per minute.