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. 2022 Nov 8;11:e81114. doi: 10.7554/eLife.81114

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© 2022, Liu et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 7. — (A) The number of metabolic pathways that was significantly upregulated or downregulated (FDR <0.05) in GINS6 versus the other subtypes among each of nine metabolic categories. (B) GSEA plots of nine lipid metabolism pathways (FDR <0.001). (C) Principal component analysis of all samples in the discovery cohort for the mRNA expression of lipid metabolic genes. (D) SSEA-based framework further confirmed that GINS6 predominantly enriched high-ranking samples with stronger lipid signature scores. (E) Metabolite-protein interaction network (MPIN) was established via nine GINS6-specific genes with broad and tight connections with lipid metabolites. (F) Metabolomics results further demonstrated that GINS6 featured by abundant fatty acids metabolites. Wilcoxon test. *p<0.05, ***p<0.001, ****p<0.0001.

Figure 7—figure supplement 1. — (A) The number of metabolic pathways that was significantly upregulated or downregulated (FDR <0.05) in GINS6 versus the other subtypes among each of nine metabolic categories. (B) GSEA plots of nine lipid metabolism pathways (FDR <0.001). (C) Principal component analysis of all samples in the discovery cohort for the mRNA expression of lipid metabolic genes. (D) SSEA-based framework further confirmed that GINS6 predominantly enriched high-ranking samples with stronger lipid signature scores. (E) Metabolite-protein interaction network (MPIN) was established via nine GINS6-specific genes with broad and tight connections with lipid metabolites. (F) Metabolomics results further demonstrated that GINS6 featured by abundant fatty acids metabolites. Wilcoxon test. *p<0.05, ***p<0.001, ****p<0.0001.