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. 2022 Nov 8;11:e81114. doi: 10.7554/eLife.81114

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© 2022, Liu et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 8. — (A) Supervised approach identified phenotype origins peculiar to individual GINS classes. (B–H) Unsupervised-based GSVA showed the distribution of enterocyte (B), inflammatory (C), transit-amplifying (D), stem-like (E), goblet-like (F), serrated CRC-like (G), conventional CRC-like (H) scores among six subtypes. Kruskal-Wallis test. (I) The distribution of WNT signaling score in different cell-like tumors. Kruskal-Wallis test. (J) CRC cellular phenotypes correlated with colon-crypt location and WNT signaling. (K) Fractions of the crypt base and top phenotypes among six subtypes. Nearest template prediction (NTP) algorithm based on published signatures assigned each sample into the crypt base and top phenotypes in the discovery cohort. (L) GSVA analysis revealed that GINS2 displayed superior stemness abundance relative to other subtypes. (M) Radar plot showed autocrine stimulation loops in GINS subtypes.

Figure 8—figure supplement 1. — (A) Supervised approach identified phenotype origins peculiar to individual GINS classes. (B–H) Unsupervised-based GSVA showed the distribution of enterocyte (B), inflammatory (C), transit-amplifying (D), stem-like (E), goblet-like (F), serrated CRC-like (G), conventional CRC-like (H) scores among six subtypes. Kruskal-Wallis test. (I) The distribution of WNT signaling score in different cell-like tumors. Kruskal-Wallis test. (J) CRC cellular phenotypes correlated with colon-crypt location and WNT signaling. (K) Fractions of the crypt base and top phenotypes among six subtypes. Nearest template prediction (NTP) algorithm based on published signatures assigned each sample into the crypt base and top phenotypes in the discovery cohort. (L) GSVA analysis revealed that GINS2 displayed superior stemness abundance relative to other subtypes. (M) Radar plot showed autocrine stimulation loops in GINS subtypes.