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. Author manuscript; available in PMC: 2023 Apr 30.
Published in final edited form as: J Mol Biol. 2022 Jan 4;434(8):167440. doi: 10.1016/j.jmb.2021.167440

Figure 5.

Figure 5.

Translation by E. coli ProM of a non-frameshifting mRNA sequence AUG-CCA-A or a frameshifting mRNA sequence AUG-CCC-A as captured by cryo-EM structures. Reading of (A) the non-frameshifting sequence and (B) the frameshifting sequence in the A site; reading of (C) the non-frameshifting sequence and (D) the frameshifting sequence during mid-translocation; and reading of (E) the non-frameshifting sequence and (F) the frameshifting sequence near the end of translocation. For complexes C-F, the translocation factor EF-G and the nonhydrolyzable analog GDPcP of GTP are present.