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. Author manuscript; available in PMC: 2022 Nov 14.
Published in final edited form as: Cell Rep. 2022 Oct 25;41(4):111539. doi: 10.1016/j.celrep.2022.111539

Figure 7. m1G37 methylation of tRNA resolves codon usage bias of the cmo5U34-modified major isoacceptor Pro(UGG) with medical relevance.

Figure 7.

(A) (Top) In the presence of m1G37 (a red circle), the cmo5U34-modified Pro(UGG) can read all four Pro codons. (Bottom) In the absence of m1G37 (an open circle), the major isoacceptor is insufficient to read CC[C/U], requiring Pro(GGG) to assume the role.

(B) Upon targeting TrmD by an inhibitor, while cell viability is diminished, a potential resistance mechanism can occur by proS mutations. This resistance would be thwarted if the bacterial species lacks Pro(GGG).