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. 2022 Oct 26;15:937350. doi: 10.3389/fnmol.2022.937350

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Copyright © 2022 Sun, Baker, Wilson, Brady, Mychasiuk, Yamakawa, Vo, Wilson, McDonald and Shultz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Behavior findings in male rats. (A) During water maze acquisition, male LI rats spent significantly longer than sham rats to find the platform on trials 3, 7, 8, 9, and 10. (B) During water maze reversal, LI + VEGF rats took longer to find the platform than all other groups. (C) LI rats had fewer direct and circle swims than sham rats during acquisition. During reversal, both VEGF and LI rats had fewer direct and circle swims. (D) LI rats had more slips and falls than the shams on beam task. *, LI rats significantly different than sham rats; #, VEGF treated rats significantly different than VEH treated rats; ***, different than all other groups; p < 0.05. Sham+VEH, n = 10; Sham+VEGF, n = 10; LI + VEH, n = 11; LI + VEGF, n = 11; except for beam, Sham+VEH, n = 9 Sham+VEGF, n = 8; LI + VEH, n = 10; LI + VEGF, n = 10. Error bar = SEM; water maze block = mean of every two trials.