Figure 10.

vWF immunohistochemistry in skin biopsies in non–painful (NPDPN Q+SOC) and painful (PDPN Q+SOC) Diabetic Peripheral Neuropathy following Capsaicin 8% patch Qutenza (Q) treatment. Vessel density (vWF, % area) in NPDPN Q+SOC and PDPN Q+SOC at baseline (Q PRE) and statistically no significant differences between NPDPN and PDPN before (Q PRE, p = 0. 83; Mann–Whitney test; n = 24 NPDPN Q+SOC) or 3 months after treatment (Q POST, p = 0. 90, Mann–Whitney test). Statistically significant increases (all ***p < 0.0001, Mann–Whitney test) between control group and baselines (Q PRE) or 3 months after treatment (Q POST) in both NPDPN Q+SOC and PDPN Q+SOC.