Skip to main content
. 2022 Oct 26;13:998904. doi: 10.3389/fneur.2022.998904

Figure 6.

Figure 6

PGP9.5 immunohistochemistry in 50 μm sections from skin biopsies in non–painful (NPDPN Q+SOC) and painful (PDPN Q+SOC) Diabetic Peripheral Neuropathy following Capsaicin 8% patch Qutenza (Q) treatment. Intra–epidermal (IENF/mm, A) and sub–epidermal fiber density (SENF, % area, B) in NPDPN and PDPN. (A) IENFs in NPDPN Q +SOC and PDPN Q+SOC at baseline (Q PRE) and statistically non–significant difference before (Q PRE, p = 0. 44; Mann–Whitney test; n = 24 NPDPN Q+SOC and n = 25 PDPN Q+SOC) or 3 months after treatment (Q POST, p = 0.52, Mann–Whitney test). Statistically significant difference between control group and baseline (Q PRE), and after treatment (Q POST) (Mann–Whitney test). (B) SENFs in NPDPN Q+SOC and PDPN Q+SOC at baseline (Q PRE) and statistically significant difference before (Q PRE, *p = 0. 01; Mann–Whitney test; n = 24 NPDPN Q+SOC and n = 25 PDPN Q+SOC) but not 3 months after treatment (Q POST, p = 0.06, Mann–Whitney test). Statistically significant decreases between control group and baseline (Q PRE) but less significance after treatment (Q POST) (Mann–Whitney test) in NPDPN Q+SOC but not PDPN Q+SOC. ***Highly significant.