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. 2022 Oct 26;13:998904. doi: 10.3389/fneur.2022.998904

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Copyright © 2022 Anand, Privitera, Donatien, Fadavi, Tesfaye, Bravis and Misra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GAP 43 immunohistochemistry from skin biopsies in non–painful (NPDPN Q+SOC) and painful (PDPN Q+SOC) Diabetic Peripheral Neuropathy following Capsaicin 8% patch Qutenza (Q) treatment. Sub–epidermal fiber density (SENF, % area) in 30 μm sections in NPDPN Q+SOC and PDPN Q+SOC at baseline (Q PRE) and statistically no significant difference in NPDPN and PDPN before (Q PRE, p = 0. 94; Mann–Whitney test; n = 24 NPDPN Q+SOC) or 3 months after treatment (Q POST, p = 0. 38, Mann–Whitney test). Statistically no significant difference between control group and baselines (Q PREs), but significant increases after treatment (Q POSTs) in both NPDPN Q+SOC and PDPN Q+SOC (*p = 0.04 and *p = 0.02 respectively, Mann–Whitney test). **Very significant, ***Highly significant.