Table 2.

Absence and presence of coagulation cascade proteins in vertebrates

	V	VII	VIII	IX	X	XI	XII	XIIIA	XIIIB	C	Z	S	THRB	PLG	KLKB	vWF
Jawless vertebrate (n = 2)	?	+	−	−	+	−	−	−	−	−	−	+	+	+	−	+
Cartilaginous fish (n = 1)	+	+	+	+	+	−	−	+	−	+	+	+	+	+	−	+
Ray-finned fish (n = 1)	+	+	+	+	+	−	−	+	+	+	+	+	+	+	−	+
Lobe-finned fish (n = 1)	+	+	+	+	+	−	−	+	+	+	+	+	+	+	+	+
Amphibian (n = 1)	+	+	+	+	+	−	+	+	+	+	+	+	+	+	+	+
Reptile (n = 2)	+	+	+	+	+	−	+	+	+	+	+	+	+	+	+	+
Bird (n = 1)	+	+	+	+	+	−	−	+	+	+	+	+	+	+	+	+
Monotreme (n = 1)	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+
Marsupial (n = 1)	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+
Cetacean (n = 2)	+	+	+	+	+	+	−	+	+	+	+	+	+	+	−	+
Placental (n = 3)	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+

Coagulation factors are depicted by using only their number (i.e., Coagulation factor V is depicted as V), S: Vitamin K-dependent protein S, THRB: Prothrombin, PLG: Plasminogen, KLKB: Plasma Kallikrein, vWF: von Willebrand factor. + , − , ? represent, presence, absence and unknown, respectively. Most of the data were found to be in agreement with current literature (Jiang and Doolittle (2003); Ponczek et al (2008, 2012, 2020); Doolittle (2009)). Data in disagreement with current literature or are new in this study are marked in bold