Table 2.
Characteristics of 17 animal model studies of the effect of probiotics on wound healing
| First author, year | Study type | Probiotic | Findings (effect of probiotics on wound) |
|---|---|---|---|
| Valdez, 2005 [7] | Animal model study and in vitro study | L. plantarum | Enhanced wound healing |
| Brachkova, 2011 [9] | Animal model study | L. plantarum | Reduction of Pseudomonas aeruginosa in wound |
| Nasrabadi, 2011 [10] | Animal model study | L. brevis and L. plantarum | Decreased inflammation and improved wound healing |
| Jones, 2012 [11] | Animal model study | L. fermentum | Enhanced wound healing |
| Poutahidis, 2013 [12] | Animal model study | L. reuteri | Enhanced wound healing |
| Partlow, 2016 [14] | Animal model study | S. bouladrii | Unimproved wound healing, unchanged microbiome |
| Argenta, 2016 [15] | Animal model study | L. plantarum | Decreased mortality and production of inflammatory markers (TNF-α, IL 6 and 10), less septicemic accumulation in organs |
| Satish, 2017 [16] | Animal model study | L. plantarum | Reduced severity and length of infection and collagen concentration (less scarring) |
| Oryan, 2018 [17] | Animal model study | S. cerevisiae | Enhanced burn wound healing |
| Ong, 2019 [18] | Animal model study | L. plantarum | Enhanced wound healing, suppressed Staphylococcus aureus infection at wound |
| Tagliari, 2019 [19] | Animal model study | L. paracasei, B. lactis, L. rhamnosus, L. acidophilus | Enhanced wound healing, increased collagen production |
| Khodaii, 2019 [20] | Animal model study | L. reuteri | Enhanced collagen production, accelerated wound healing |
| Han, 2019 [21] | Animal model study | L. reuteri | Promoted wound healing through activation of GMSCs |
| Han, 2020 [26] | Animal model study | L. reuteri | Inhibited inflammation and enhanced wound healing through promoting MSCs |
| Mohtashami, 2020 [23] | Animal model study | L. bulgaricus, L. plantarum | Enhanced wound healing |
| Ong, 2020 [24] | Animal model study | L. plantarum | Suppressed Staphylococcus aureus, and thereby improved wound healing |
| Moreira, 2021 [25] | Animal model study | L. johnsonii, L. paracasei, and L. rhamnosus | Promoted skin wound closure and decreased scar formation and inflammation |
L., Lactobacillus; S., Saccharomyces; B, Bifidobacterium; GMSC, gingival mesenchymal stem cells; MSC, mesenchymal stem cell