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. 2022 Oct 26;16:997360. doi: 10.3389/fncel.2022.997360

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Copyright © 2022 Ge, Cai and Pan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Persistent pain activates PBN–CeAl inputs in PBN-input-only CeAl cells. (A,B) PBN-elicited lEPSC traces (A) and group data of lEPSC amplitude (B) in the PBN-input-only cells in CeAl from the saline and CFA rat groups. (C–G) mEPSC traces (C) and group data of mEPSC amplitude (D,E) and mEPSC frequency (F,G) in the PBN-input-only cells in CeAl from the saline and CFA rat groups. (H,I) Representative current traces of AMPA EPSCs and NMDA EPSCs (H), and group data of AMPA/NMDA ratio in the saline and CFA groups. (J) Representative current traces of a lEPSC and an eEPSC, and a compound EPSC (cEPSC) evoked by simultaneous light and electrical stimulation in the same dual-input cell. (K) Group data of amplitudes of the sum of the lEPSC and eEPSC, and cEPSC in each dual-input cell. *p < 0.05.