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. 2022 Aug 8;12(11):4204–4223. doi: 10.1016/j.apsb.2022.07.023

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© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Safety evaluation of BSA-MHI148@SRF nanoparticles in vivo. (A) Photographs of hemolysis assay of BSA-MHI148@SRF nanoparticles (double distilled water as the positive control, and saline as the negative control) and corresponding hemolysis rate. (B) Serum biochemistry data of liver function (ALT and AST) and kidney function (BUN and CR) (n = 3). (C) Representative H&E images of the major organs (heart, liver, spleen, lung, and kidney) collected from mice after 14 days of various therapies, scale bar = 100 μm. Data are demonstrated as mean ± SD. (+ L) represents the tumors treated with laser irradiation.