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12E-Rumbrin (2) inhibits HIV-1 replication by blocking viral integration. (A–C) VSV-G pseudotyped NL4-3Luc R-E- viruses were used to infect SupT1 cells with the treatment of DMSO, 4 nmol/L EFV, 25 nmol/L RAL, or 2. HIV-1 RT DNA (A), integrated DNA (B), and 2-LTR circles (C) were quantified by RQ-PCR using the corresponding primers (Table S1). ∗P < 0.05.
