Table 2.
Application of biotechnology in pharmaceutical manufacturing control.
| Category | Technique | Response | Application | Ref. |
|---|---|---|---|---|
| Biological-chemical-coupling technology | DART-MS-enzyme | Chemical components and biological activities | Danshen injection | 61 |
| ABTS ± CE | Major antioxidants in injection | Shuxuening injection | 62 | |
| Metabolomics-chemometrics | Bioactive-chemical quality marker combination | Pollen of T. orientalis | 63 | |
| Biosensors for PAT | Enzyme based SPR | Acceptable therapeutic monitoring | Bromocriptine | 64 |
| HF-AS | Lipase-binding ligands | Lotus leaf extracts | 65 | |
| TPE-fluorescent probe | Monitor ACE activity | Tongmaiyangxin pill | 66 | |
| FRET fluorescent acceptor | Patulin and zearalenone | Extracts of TCM | 67 | |
| Aptamer biosensor | Rapid detection of pathogenic E. coli | Licorice extracts | 68 | |
| Protein chip for target enzyme | PAD | Hypoglycemic and xanthine oxidase inhibitory activity | Mulberry, lotus and Salvia miltiorrhiza extracts | 69, 70, 71 |
| Dual-channel microfluidic chip | Multiple biomarker assay | Qishen Yiqi Pill | 72 | |
| Biological soft sensing technology | HSI-AI-CNN | Physical, chemical and biological properties | Shuxuening injection | 73 |
| NIR-machine learning | Chemical compounds and anti-inflammatory activity | Chrysanthemum extracts | 74 |