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. 2022 Mar 29;12(11):4235–4248. doi: 10.1016/j.apsb.2022.03.015

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© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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In vivo detoxification of PFTs by RM-PL following intravenous toxin challenge. (A–C) Survival curves of mice treated with an intravenous injection of RM-PL 2 min after the injection of a lethal dose of (A) Hlα, (B) LLO and (C) SLO (n = 5). (D, E) The H&E stained slices of the lung from mice treated with RM-PL after intravenous (D) Hlα and (E) LLO challenge, respectively. (F) The H&E stained slices of the heart from mice treated with RM-PL after intravenous SLO challenge. Scale bar = 50 μm. Normal mice without intravenous toxin challenge was treated with PBS and served as a control.