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. 2022 Nov 9;61:129–138. doi: 10.1016/j.mattod.2022.11.001

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© 2022 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Multianalyte detection capability of BiosensorX. (a) 3D rendering of the stacked BiosensorX. (b-f) Personalized ß-lactam antibiotic dosing in a simulated COVID-19 patient. (b) Methodology of simultaneous measurement of antibiotic concentration and detection of viral RNA in clinical samples. (c) Overview of the drug clearance behavior in a simulated COVID-19 patient (d) before, (e) 5 minutes, (f) 240 minutes after “antibiotic administration” (N = 1). (g-i) Clinical samples from a healthy subject and two COVID-19 patients analyzed with BiosensorX. Current densities for (g) a healthy subject, (h) a patient with Ct 17.8 and (i) a patient with Ct 19. Signals obtained from the samples of diseased patients were normalized to their respective target-equivalents obtained from the healthy subject and are therefore presented in arbitrary units. N = 2, Error bars represent + SD.