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. 2022 Sep 1;127(10):1760–1772. doi: 10.1038/s41416-022-01956-7

Fig. 6. Exosomal ANGPTL4 contributes to radioresistance via inhibition of ferroptosis in vivo.

Fig. 6

a Representative xenograft tumour mass (n = 5) and the growth curves of A549 tumours injected with PBS or homologous exosomes (10 μg) once daily for 3 days before local irradiation (20 Gy) followed by continued daily injection until mice sacrifice. Exosomes were generated from normoxic A549 cells with ANGPTL4 overexpression and hypoxic A549 cells with ANGPTL4 knockdown, respectively. b, c Quantification of immunohistochemical staining of GPX4 and ANGPTL4 in A549 xenograft tumours injected with PBS or indicated exosomes as above. **P < 0.01.