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. 2022 Nov 8;13:6752. doi: 10.1038/s41467-022-34467-3

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Abundance of CD15^high neutrophils in the tumor identifies High (HN) and Low (LN) neutrophil subgroups of non-metastatic resectable CRC patients (1). Elevated SDF-1 levels in HN tumors reshape the functional state of infiltrating neutrophils (2), promoting their retention (3) and activation (4) at the tumor site. The contact-mediated interaction with neutrophils (5) pushes effector memory CD8⁺ T cells (T_EM) to produce high levels of Granzyme K (GZMK) (6), which in turn remodels the tumor microenvironment (TME) fostering EMT (7). A GZMK^high T_EM transcriptional signature effectively stratify non-metastatic resectable CRC patients and predict poor clinical outcome. Graphical model created with BioRender.com.