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. 2022 Nov 8;12:468. doi: 10.1038/s41398-022-02240-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Panel I shows Hamilton Depressive Rating Scale 6 (HDRS₆) scores for each of the three cognitive profile clusters at baseline, week 4, week 8, and week 12. Panel II shows improvement (i.e., reduction) in HDRS₆ scores in percentage for the three cognitive profile clusters at week 8 and week 12 relative to baseline. The graphs show observed group averages and the error bars denote standard deviations while the significance notation in panel II represents model estimates corrected for age and sex. * p < 0.05.