Table 4.
The logistic regression to identify the influence factors of greater KPS score improvement.
| Variables | Univariate analysis | Multivariate analysis | |
|---|---|---|---|
| p-value | OR (95% CI) | p-value | |
| Sex | 0.749 | ||
| Age | 0.668 | ||
| Pathological type (HCC = 1, ICC = 2) |
0.410 | ||
| Liver primary lesion surgeryb | 0.003* | — | — |
| Number of bone metastasisb | 0.099 | — | — |
| Sites of bone metastasisa | 0.134 | ||
| Pathological fracture | 0.553 | ||
| Orthopedic therapeutic surgeryb | 0.009* | 8.718 (2.214–35.783) | 0.003* |
| Pretreatment KPS score | 0.818 | ||
| Pretreatment NRS score | 0.319 | ||
| AFP positiveb | 0.095 | — | — |
| AFP-L3 positive | 0.283 | ||
| PIVKA positive | 0.592 | ||
Greater KPS score improvement (posttreatment KPS score minus pretreatment KPS score was greater than or equal to 20) was defined as the outcome.
OR, odds ratio; CI, confidence interval; HCC, hepatocellular carcinoma; ICC, intrahepatic cholangiocarcinoma; KPS, Karnofsky Performance Status scale; NRS, Numeric rating scale; AFP positive, AFP level ≥20 ng/ml; AFP-L3 positive, AFP-L3 percentage ≥10%; PIVKA positive, PIVKA level >40 mAU/ml.
a
Due to collinearity with “Number of bone metastasis”, it was not included in the multivariate logistic regression analysis.
b
Included in the multivariate logistic regression analysis.
*
p-value < 0.05.