Table 3.

Pathways associated with top independent mammography radiomics features at diagnosis among patients with breast cancer using gene set enrichment analysis^a, in tumour tissues and adjacent normal tissues.

				Tumour		Normal
			N of Genes	Direction	P*	Direction	P*
S(1,−1)SumAverg	Hallmark	G2M_CHECKPOINT	193	Up	4.99E-07	Down	0.751
		E2F_TARGETS	198	Up	4.99E-07	Down	0.751
		MYC_TARGETS_V1	195	Up	1.98E-04	Up	0.935
		MYC_TARGETS_V2	58	Up	9.25E-05	Down	0.107
	KEGG	DNA_REPLICATION	36	Up	8.83E-05	Down	0.947
		MISMATCH_REPAIR	23	Up	0.023	Down	0.947
		CELL_CYCLE	124	Up	0.043	Up	0.994
		PROTEASOME	44	Up	0.043	Up	0.366
WavEnLL_s-6	Hallmark	G2M_CHECKPOINT	193	Up	2.81E-07	Down	0.588
		E2F_TARGETS	198	Up	2.80E-07	Down	0.582
		MYC_TARGETS_V1	195	Up	1.16E-04	Down	0.749
		MYC_TARGETS_V2	58	Up	7.26E-05	Down	0.016
	KEGG	DNA_REPLICATION	36	Up	2.54E-05	Down	0.889
		MISMATCH_REPAIR	23	Up	0.011	Down	0.909
		RIBOSOME	86	Down	0.011	Up	0.684
		CELL_CYCLE	124	Up	0.031	Down	0.970
		PROTEASOME	44	Up	0.041	Up	0.684

N number.

*FDR-corrected P-value.

^aThis analysis was performed in breast cancer patients whose tumours have been sequenced for RNA (n = 96) and adjusted for age, menopausal status, molecular subtype, tumour stage and histologic grade.