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Schematic model showing CaMKII autonomy induced by oxidation. (1) Oxidation induces disulfide formation (2) between Cys273 and Cys290 from different CaMKII dodecamers. One subunit is colored red and one in a different dodecamer is colored green. (3) Subunit exchange occurs between the dodecamers and the disulfide is now (4) intra-dodecameric between adjacent subunits. CaMKII, calcium/calmodulin-dependent protein kinase II.
