Skip to main content
. 2022 Nov 8;13:6739. doi: 10.1038/s41467-022-34548-3

Fig. 5. Curative adoptive transfer of p21TD-Mos prolongs mouse survival in diagnosed or relapsed T-ALL-derived PDX models.

Fig. 5

a Schematic representation showing curative adoptive transfer of Co.TD-Mos or p21TD-Mos into NSG mice engrafted with T-ALL PDXs. b–d Survival of mice engrafted with T-ALL PDX#1 (****p = 1.1e-5) (b), PDX#2 (****p = 1.9e-6) (c) or PDX#3 (**p = 0.003) (d) and treated curatively, as shown in a, with Co.TD-Mos or p21TD-Mos. PDX#1 and PDX#2 were from the same patient but isolated at the diagnosis and relapse stages, respectively. In b–d, the survival data are from n = 5 mice/group. Exact p-values are indicated and determined with the log-rank Mantel-Cox (b–d) test. Source data are provided as a Source Data file.