Table 2.
Analytical performance of the evaluated sVNT assays using the pre-defined cutoff values and the newly calculated cutoff values determined using Youden's index.
| Assay | GenScript sVNT (cPass) | Dynamiker sVNT | Mindray NTAb sVNT |
|---|---|---|---|
| Pre-defined cutoff | 30% | 30% | 33.1 IU/ml |
| Sensitivity in the infected group (95% CI) | 96.2% (90.6–98.5) | 97.0% (94.1–98.5) | 97.1% (94.4–98.5) |
| Sensitivity in the vaccinated group (95% CI) | 100% (86.2–100%) | 97.0% (94.1–98.5) | 97.1% (94.4–98.5) |
| Specificity (95% CI) | 100% (94.8–100) | 100% (92.1–100) | 100% (94.9–100) |
| New cutoff for infected group | 17.1% | 14.4% | 51.3 IU/ml |
| Sensitivity using the new cutoff (95% CI) | 100% (96.5–100%) | 99.2% (95.7–100) | 97.6% (87.7–99.9) |
| New cutoff for the vaccinated group | 31.4% | 19.9% | 21.4 IU/ml |
| Sensitivity using the new cutoff (95% CI) | 100% (86.2–100%) | 100% (97.6–100) | 99.4% (96.4–100) |
| Specificity using the new cutoff (95% CI) | 100% (94.8–100) | 100% (92.1–100) | 100% (95.0–100) |