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. 2022 Nov 8;13:6747. doi: 10.1038/s41467-022-34413-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Heatmap showing the enrichments of heritability for human traits among the neuronal and non-neuronal cell types from snATAC-seq data of PFC, M1 and V1. P values were derived from LDSC enrichment tests. AD, Alzheimer’s disease; ADHD, attention deficit hyperactivity disorder; ASD, autism spectrum disorder; BD, bipolar disorder; ALS, amyotrophic lateral sclerosis; MDD, major depression disorders; SCZ, schizophrenia, T2D, type 2 diabetes. b Cell type-enrichment of dysregulated genes for neurological diseases⁷¹ in Stereo-seq sections of PFC, M1 and V1. Differentially expressed genes (Up, up-regulated genes; Down, down-regulated genes) in brains of individuals with ASD, BD or SCZ versus controls. Numbers within heatmap cells indicate odd ratio (OR) value for the enrichments. A one-sided hypergeometric test was performed for gene set overlap significance.