Table 1. Pediatric study population.
A total of 70,290 cases and 467,247 controls across eMERGE and the UK Biobank in five super-populations [EUR (European), AMR (Admixed American), AFR (African), EAS (East Asians), SAS (South Asian)] were evaluated. Pediatric-onset was defined as diagnosis before age 18 years old. Please see Supplemental Table 4 for a list of all participants, including those without pediatric-onset asthma.
| Cohort | Ancestry | Case/Control | Female/Male | Mean age in years |
|---|---|---|---|---|
| Training | All | 1,324/3,174 | 2,058/2,440 | 11.83 (5.32) |
| European | 322/1,736 | 941/1,117 | 11.82 (5.20) | |
| African | 768/727 | 697/798 | 12.55 (5.17) | |
| Admixed | 203/642 | 367/478 | 12.14 (5.15) | |
| Eastern Asian* | 21/40 | 34/27 | 11.68 (5.11) | |
| Southern Asian* | 10/29 | 19/20 | 10.95 (6.01) | |
| Validation 1 | All | 1,255/7,710 | 3,988/4,977 | 10.37 (5.97) |
| European | 386/3,982 | 1,883/2,485 | 10.90 (5.75) | |
| African | 588/1,352 | 905/1,035 | 10.04 (6.25) | |
| Admixed | 270/2,180 | 1,105/1,345 | 11.13 (5.50) | |
| Eastern Asian* | 9/114 | 62/61 | 9.69 (6.17) | |
| Southern Asian* | 2/82 | 33/51 | 10.07 (6.18) | |
| Validation 2 | All | 16,462/398,808 | 219,728/195,542 | 8.40 (4.69) |
| European | 15,586/376,234 | 207,785/184,035 | 8.10 (4.82)I | |
| African | 310/7,508 | 4,385/3,433 | 8.21 (4.70)I | |
| Admixed | 205/5,020 | 2,717/2,508 | 8.16 (5.06)I | |
| Eastern Asian | 49/1,622 | 877/794 | 7.96 (4.12)I | |
| Southern Asian | 312/8,424 | 3,964/4,772 | 9.54 (4.74)I |
I
Mean age of onset for Validation 2 cases at the time of diagnosis (see Methods)
*
Due to low sample size, subgroups identified with asterisks only included in combined adjusted PRS analysis; ancestry-specific results from these subgroups are not presented.