Table 3: Multiancestral asthma PRS performance in three independent cohorts.

The standardized PRS distribution was evaluated in a logistic regression model adjusted for age and sex as well as the 10 principal components that informed the five super populations. The Area under the curve (AUC) and 95% confidence interval (CI), odds ratio (OR) per one standard deviation (SD) and the total variation explained (pseudo R²) are shown.

Pediatric Cohorts	AUC (Full model)I	pseudo R2	OR per one SDII
European ancestry
Training	0.67 (0.64–0.70)	0.05	1.27 (1.12–1.44)
Validation 1	0.60 (0.57–0.63)	0.02	1.20 (1.08–1.34)
Validation 2	0.66 (0.65–0.67)	0.04	1.57 (1.55–1.60)
African ancestry
Training	0.57 (0.54–0.60)	0.01	1.13 (1.01–1.26)III
Validation 1	0.61 (0.58–0.63)	0.02	1.27 (1.14–1.42)
Validation 2	0.66 (0.63–0.69)	0.03	1.43 (1.24–1.65)
Admixed American ancestry
Training	0.68 (0.64–0.72)	0.07	1.61 (1.28–2.02)
Validation 1	0.64 (0.61–0.68)	0.03	1.25 (1.06–1.47)
Validation 2	0.70 (0.67–0.74)	0.07	1.63 (1.36–1.95)
Eastern Asian ancestry
Validation 2	0.73 (0.66–0.80)	0.08	1.32 (0.99–1.77)III
Southern Asian ancestry
Validation 2	0.65 (0.62–0.68)	0.03	1.32 (1.18–1.48)

^IAUC Full model includes age, sex and 10 principal components

^IIThe odds ratio per one standard deviation of PRS distribution (logistic regression P<0.0001)

^IIIFor the African Ancestry eMERGE datasets 1- Pediatric and Eastern Asian UK Biobank-Pediatric cohorts, P=0.03 and P=0.07 respectively.