Table 4.

Selected results of PheWAS applying Multiancestral Asthma PRS to Training and Validation 1 cohorts. CI: confidence interval; OR: odds ratio; PheWAS: phenome-wide association study; PRS: polygenic risk score.

DescriptionI	PheWAS-code	Case	Control	ORII	95% CI	PFDR
Positively associated with Asthma PRS
Asthma	495	12,963	70,020	2.71	2.41– 3.02	3.17×10−65
Asthma with exacerbation	495.2	3,043	70,020	4.72	3.74 – 5.95	3.39×10−39
Emphysema	508	8,276	73,217	1.78	1.56 – 2.05	1.22×10−16
Chronic obstructive asthma	495.1	1,433	70,020	3.23	2.35 – 4.45	4.90×10−13
Type 1 diabetes	250.1	4,283	69,292	1.91	1.58 –2.30	1.16×10−11
Chronic airway obstruction	496	8,056	70,020	1.56	1.36 –1.80	5.57×10−10
Respiratory failure	509	6,029	73,217	1.61	1.37 – 1.88	3.05×10−9
Wheezing	512.1	2,234	47,495	2.17	1.68 – 2.82	4.37×10−9
Diabetes mellitus	250	19,764	69,292	1.34	1.21 – 1.48	9.36×10−9
Eosinophilic esophagitis	530.15	607	62,044	3.85	2.38 –6.20	3.40×10−8
Type 2 diabetes	250.2	19,137	69,292	1.32	1.19 – 1.46	9.78×10−8
Diseases of white blood cells	288	4,694	77,026	1.61	1.35 –1.91	1.14×10−7
Allergic reaction to food	930	1,688	65,842	2.25	1.66 – 3.04	1.49×10−7
Negatively associated with Asthma PRS
Postmenopausal disorders	627	11,313	75,725	0.55	0.48 – 0.63	8.00×10−18
Peripheral enthesopathies	726	16,894	66,608	0.64	0.57 –1.71	6.31×10−17
Hypercholesterolemia	272.11	19,899	51,696	0.62	0.55 –0.69	6.55×10−17
Hematuria	593	7,632	68,213	0.55	0.48 – 0.64	2.50×10−16
Benign neoplasm of skin	216	11,233	79,947	0.63	0.56 – 0.71	1.86×10−14
Disorders of lipid metabolism	272	41,493	51,696	0.73	0.67 –0.80	1.04×10−11
Hyperlipidemia	272.1	41,299	51,696	0.73	0.67 – 0.80	1.11×10−11
Disorders of synovium	727	9,291	66,608	0.64	0.56 –1.73	3.65×10−11
Cataract	366	14,306	81,833	0.67	0.60 –0.76	5.14×10−11
Carbohydrate transport disorder	271	1,410	97,301	0.36	0.27 – 0.49	1.34×10−10
Disaccharide malabsorption	271.3	1,302	97,301	0.35	0.25 – 0.48	1.40×10−10
Elevated prostate specific antigen	796	2,746	84,778	0.53	0.41 – 0.67	2.92×10−7

^ISelected results at false discovery rate P_FDR<0.05. The complete lists of traits are included in Supplemental Table 5.

^IIOR<1 indicates negative association of trait with asthma PRS