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. Author manuscript; available in PMC: 2023 Nov 15.
Published in final edited form as: J Immunol. 2022 Nov 15;209(10):1973–1986. doi: 10.4049/jimmunol.2200503

Figure 12. NOX2-derived ROS is critical for S. aureus containment and leukocyte recruitment during craniotomy infection.

Figure 12.

C57BL/6J wild-type (WT) and NOX2 knockout (KO) mice (n=25-30/group) were infected with a S. aureus-dsRed strain and sacrificed at days 3 (A, C, and E) and 7 (B, D, and F) for quantification of (A and B) bacterial burden, (C and D) cell infiltrates in the brain, galea, and bone flap, and (E and F) dsRed median fluorescent intensity (MdFI) as an indicator of intracellular bacteria. Results are combined from three independent experiments and analyzed by an unpaired two-tailed Student t-test (*, p < 0.05; **, p < 0.01; ***, p < 0.001; and ****, p < 0.0001).