Figure 9. Microglial and leukocyte clusters are typified by unique transcriptional pathways during S. aureus craniotomy infection.
Pathways that were differentially expressed in (A) microglia, (B), monocyte/macrophage, and (C) granulocyte clusters in the brain using total events (dsRed+ and dsRed−) identified by scRNA-seq. Significance of the normalized enrichment scores (NES) for gene set enrichment analysis (GSEA) is denoted (*, p < 0.05; **, p < 0.01; ***, p < 0.001; and ****, p < 0.0001). H= Hallmark pathway; R= Reactome pathway; WP= WikiPathways.