Table 3.
Neuropathologic subtypes of AD TREM2 variants and AD TREM2 wild-type
| AD TREM2 variants | AD TREM2 wild-type | p value (Fisher’s exact test) | |
|---|---|---|---|
|
| |||
| N | 21 | 23 | |
|
| |||
| Typical AD, n (%) | 15 (71.43 %) | 21 (91.3 %) | 0.046* (Typical AD vs Hippocampal-sparing AD) |
| Amnestic syndrome, n | 8 | 18 | |
| (Clinical diagnosis) | |||
| Probable AD | 8 | 18 | |
| Non-amnestic syndrome, n | 7 | 3 | |
| (Clinical diagnosis) | |||
| svPPA | 1 | 0 | |
| Probable AD, language impairment-predominant | 1 | 0 | |
| CVD/AD | 1 | 0 | |
| DLB | 1 | 1 | |
| FTD-NOS | 1 | 0 | |
| Behavioral/dysexecutive variant of AD | 1 | 0 | |
| bvFTD | 1 | 1 | |
| CBS | 0 | 1 | |
|
| |||
| Hippocampal-sparing AD, n (%) | 6 (28.57 %) | 1 (4.35 %) | |
| Amnestic syndrome, n | 2 | 0 | |
| (Clinical diagnosis) | |||
| Probable AD | 2 | 0 | |
| Non-amnestic syndrome, n | 4 | 1 | |
| (Clinical diagnosis) | |||
| lvPPA | 1 | 0 | |
| PPA, mixed | 1 | 0 | |
| MND | 1 | 0 | |
| PCA | 1 | 0 | |
| FTD-NOS | 0 | 1 | |
|
| |||
| Limbic-predominant AD, n (%) | 0 | 1 (4.35 %) | |
| Typical, amnestic AD, n | 0 | 1 | |
| (Clinical diagnosis) | |||
| Probable AD | 0 | 1 | |
*
p<0.05 is statistically significant.
ADNC Alzheimer’s disease neuropathologic change, svPPA semantic variant of primary progressive aphasia, CVD cerebrovascular disease, DLB dementia with Lewy bodies, FTD-NOS frontotemporal dementia, not otherwise specified, bvFTD behavioral variant of frontotemporal dementia, CBS corticobasal syndrome, PPA primary progressive aphasia, lvPPA logopenic variant of primary progressive aphasia, MND motor neuron disease, PCA posterior cortical atrophy