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. Author manuscript; available in PMC: 2023 Nov 15.
Published in final edited form as: J Immunol. 2022 Nov 15;209(10):1950–1959. doi: 10.4049/jimmunol.2200495

Figure 2: Effect of E6020 adjuvant in the antibody responses to T-independent (NP-Ficoll) immunization.

Figure 2:

Age matched C57BL/6J WT (circles) and TLR4-SNP (squares) mice were immunized on days 0 and 21 with NP-Ficoll (Antigen alone; open symbols, solid lines) or with NP-Ficoll + E6020 (Antigen + Adjuvant; filled symbols, dashed lines). Serum was harvested from individual mice on days 0, 4, 10, 17, 25, and 31 post-prime. NP-specific IgM (top panel) and IgG (bottom panel) titers were measured by ELISA. Data were pooled from two independent experiments with 3–5 mice/treatment group/experiment. Statistical analysis (Repeated Measures 2-Way ANOVA with Sidak’s post-hoc comparison) was performed on the log transformed data.