Table 1.

Summary of mouse genotypes and NOX2 activity^*

Genotype	Resident Macrophage NOX2	Neutrophil NOX2	Monocyte NOX2
Ncf2 fl/fl	WT	WT	WT
Ncf2 LysMCre	5%	50%	WT
Ncf2 S100A8Cre	WT	20%	WT
Ncf2Cybb S100A8Cre	WT	10%	WT
Ncf2 KO	0	0	0

^*For resident alveolar and peritoneal macrophages, the percentage of macrophages that were nitroblue tetrazolium-positive following stimulation with serum-opsonized zymosan is shown. Wild-type (WT) corresponds to ≥95% nitroblue tetrazolium-positive. For neutrophils, the percent reduction of NOX2 activity compared to wild-type neutrophils is shown, as determined using the cytochrome C assay. Monocyte NOX2 activity was determined by flow cytometry and was at WT levels, expect for Ncf2^KO