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. Author manuscript; available in PMC: 2023 Nov 9.
Published before final editing as: Ann Rheum Dis. 2022 May 9:annrheumdis-2021-221867. doi: 10.1136/annrheumdis-2021-221867

Figure 4. Regulation of inflammatory and catabolic genes by KLF4 and KLF2 in human OA chondrocytes, meniscal cells and synoviocytes on IL-1β stimulation.

Figure 4.

Cells were transfected with Ad-EGFP, Ad-KLF2 or Ad-KLF4, and RNA was collected 48 hours after adenoviral transfection and 6 hours after treatment with 10 ng/ml of interleukin-1β (IL-1β). (A) n=5 donors were used for human OA chondrocytes. (B) n=4 donors were used for human meniscal cells. (C) n=3 donors were used for human synoviocytes. mRNA levels are expressed as means±SE, relative to Ad-EGFP without IL-1β as controls. *P<0.05, **P<0.01 versus Ad-EGFP, Dunnett’s test. Results of one-way mixed-effects ANOVA test are shown in supplementary table 2.