Table 3.
The study of intestinal Streptococcus in gastric cancer.
| Year | Author | Subjects | Region/country | Method | Samples | Main findings | Reference |
|---|---|---|---|---|---|---|---|
| 2019 | Qi | 116 patients with gastric cancer and 88 healthy controls | Shanxi Province, China | 16S rRNA gene sequencing | Feces | 12 bacterial genera, including Lactobacillus and Streptococcus, were enriched in GC. | Qi et al., 2019 |
| 2020 | Wu | 134 patients with gastric cancer and 58 matched healthy controls | Jiangsu Province, China | 16S rRNA and 18S rRNA gene sequencing | Feces | Streptococcus mitis and Streptococcus salivarius subsp. in stool specimens were associated with the risk of gastric cancer. | Wu et al., 2020 |
| 2021 | Liu | 38 patients with gastric cancer and 35 healthy volunteers | Shandong Province, China | 16S rRNA gene sequencing | Feces | The facultative anaerobic (aerotolerant) bacteria were Enterobacteriaceae, Escherichia and Streptococcaceae, and the abundances of all were elevated in the intestine of gastric cancer patients | Liu S. et al., 2021 |
| 2021 | Yu | 49 patients with gastric cancer (C group), 49 healthy control (N group)，26 patients were divided into liver metastasis group (L group) and nonliver metastasis group (M group)(n = 13). | Wuhan, China | 16S rRNA gene sequencing | Feces | At the genus level, lactobacillus and streptococcus were enriched in group C. By comparing group L with group M, streptococcus was identified as a microorganism that could predict liver metastasis of gastric cancer. | Yu et al., 2021 |
| 2021 | Zhang | 83 cases of noncardia gastric cancer, 54 cases of chronic atrophic gastritis, 29 cases of colorectal cancer and 61 healthy individuals | Zhejiang Provence, China | 16S rRNA gene sequencing | Feces | The abundance of the Streptococcus genus was increased in the intestinal microbiota of gastric cancer patients. | Zhang Y. et al., 2021 |
| 2021 | Zhang | 22 patients with gastric cancer and 30 healthy (Hp negative, no gastrointestinal symptoms) | Qinghai Province, China | 16S rDNA gene sequencing | Feces | At the genus level, Prevotella, Streptococcus and Lactobacillus abundances were higher in the gastric cancer group than in the healthy group and the difference was statistically significant. | Zhang Z. et al., 2021 |